Determination of Enantiomeric Excess of Metolachlor from Chiral Synthesis using the Agilent 1260 Infi nity Analytical SFC System
ثبت نشده
چکیده
This Application Note describes the development of a method for the separation of four stereoisomers, which were derived from a compound with two steric centers. The method was developed using an Agilent 1260 Infi nity Analytical Supercritical Fluid Chromatography (SFC) solution with Agilent ChemStation Method Scouting Wizard software. The developed method was used to compare the ratio of stereoisomers obtained from racemic and stereoselective syntheses. (aS,1‘S) Metolachlor (aR,1‘S) Metolachlor (aR,1‘R) Metolachlor (aS,1‘R) Metolachlor
منابع مشابه
Determination of Enantiomeric Excess of Metolachlor from Chiral Synthesis using the Agilent 1260 Infinity Analytical SFC System
This Application Note describes the development of a method for the separation of four stereoisomers, which were derived from a compound with two steric centers. The method was developed using an Agilent 1260 Infinity Analytical Supercritical Fluid Chromatography (SFC) System with Agilent ChemStation Method Scouting Wizard software. The developed method was used to compare the ratio of stereois...
متن کاملEnantiomer separation of non - steroidal anti - infl ammatory drugs Using Daicel immobilized polysaccharide - derived chiral columns and the Agilent 1260 Infi nity Analytical SFC System Application
The enantiomer separation by supercritical fl uid chromatography (SFC) of six profen drugs was investigated on the new generation of chiral columns from Daicel Corporation, that are packed with the immobilized polysaccharide-derived chiral stationary phases CHIRALPAK IA, CHIRALPAK IB, CHIRALPAK IC, and CHIRALPAK ID. Methanol, ethanol, 2-propanol and acetonitrile were used in combination with tr...
متن کاملSeparation of enantiomers and conformers of Tofi sopamon
Due to different physiological activities, the chromatographic separation of enantiomers is an important task in drug discovery and development. The determination of the enantiomeric excess (ee) is often done with supercritical fl uid chromatography (SFC) in combination with chiral stationary phases. Since fi nding the right stationary phase that provides separation of the enantiomers is diffi ...
متن کاملTransfer of USP Cholecalciferol Normal-phase HPLC Method to SFC Using the Agilent 1260 Infi nity Hybrid SFC/UHPLC System
The Agilent 1260 Infi nity Hybrid SFC/UHPLC System offers a fast, reliable, green, robust, and cost-effective solution by coupling the advantages of HPLC and the benefi ts of supercritical fl uid chromatography (SFC). This Application Note describes the conversion of the United States Pharmacopeia (USP) normal-phase HPLC method for cholecalciferol assay to an SFC method using serially coupled c...
متن کاملDetermination of Vitamin E in Olive Oil Using the Agilent 1260 Infi nity Analytical SFC System Rapid, high-resolution separation of all isomers of tocopherol and tocotrienol
This Application Note demonstrates the separation of eight tocopherol and tocotrienol compounds by supercritical fl uid chromatography (SFC) using the Agilent 1260 Infi nity Analytical SFC system. Calibration curves were generated for all compounds, and a real-life virgin olive oil sample was analyzed. The limits of detection and quantifi cation (LOD and LOQ) were determined as well as relative...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015